3 edition of Annual Review of Chronopharmacology found in the catalog.
|LC Classifications||December 1984|
|The Physical Object|
|Pagination||xvi, 104 p. :|
|Number of Pages||72|
nodata File Size: 8MB.
Therefore, it is not surprising that many aspects of pharmacology and toxicology also oscillate according to the same 24-h clocks.
Daily oscillations in abundance of proteins necessary for either drug absorption or metabolism result in circadian pharmacokinetics, and oscillations in the physiological systems targeted by these drugs result in circadian pharmacodynamics. There were circadian stage- dependent changes in the concentrations of CPT-11 and its major metabolite SN-38; 7- ethyl-10-hydroxycamptothecin in plasma.sleep and wake cycles. Our internal clocks are genetically determined. Previous work has shown that by charting circadian rhythms, it has been possible to find optimal times to deliver a dose of drug, such that it is most efficacious in killing cancer cells and least harmful to normal tissues.
The dosing-time dependencies of diltiazem on BP are different; the morning once-daily ingestion schedule exerts strong effect on nighttime BP, whereas the evening one produces a strong effect on it during the morning and afternoon.
Aim of chronobiology is optimization of pharmacotherapeutics, taking into consideration-rhythm dependencies in kinetics and dynamics of medications, predictable in time variability in the manifestation and severity of diseases.
In humans, variations during the Annual Review of Chronopharmacology h day in pharmacokinetics chrono-pharmacokinetics have been shown for cardiovascularly active drugs propranolol, nifedipine, verapamil, enalapril, isosorbide 5-mononitrate and digoxinanti-asthmatics theophylline and terbutalineanticancer drugs, psychotropics, analgesics, local anaesthetics and antibiotics, to mention but a few. The two layers both contain a drug dose. Based on these physiological and pathophysiological findings it is not surprising that desired and undesired effects of drugs used in cardiology as well as their pharmacokinetics exhibit circadian temporal dependencies.
The goal of chronopharmacology is to optimize the therapeutic effect and control or reduce the adverse effects without altering the functioning of the drug in the body. Therefore, full prediction of chronopharmacology in pathological contexts will likely require a systems biology approach that considers chronointeractions among different clock-regulated systems.
A better understanding of periodic and thus predictable changes in drug effects can be attained by consideration of complementary concepts:- a. org FIND OUT AT OUR DATABASE 3. Bedtime dosing of long-acting antihypertensive agents helps restore BP control in the morning and bring back normal circadian rhythm of BP non dipper-dipper.
but can be followed down to the cellular and subcellular level of the sympathetic nervous system. Chronopharmacology became recognized as a scientific domain of investigation only in the early 1970s 1-3. org FIND OUT AT OUR DATABASE Annual Review of Chronopharmacology.
Lag times can be varied by changing the barrier formulation or the coating thickness.
A rapidly growing number of circadian about-24-hour 1-11 , circannual about-1-year 12 and other 13, 14 rhythms Table 1 of susceptibility are being reported for various life forms including human beings.
In animals maintained under the conditions of artificial constant light the toxicity rhythm was perversed within the first hours after injection and improved on subsequent observation.